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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KCNQ3
All Species:
26.06
Human Site:
S421
Identified Species:
71.67
UniProt:
O43525
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43525
NP_004510.1
872
96742
S421
E
Q
L
E
A
A
S
S
Q
K
L
G
L
L
D
Chimpanzee
Pan troglodytes
XP_001134760
872
96660
S421
E
Q
L
E
A
A
S
S
Q
K
L
G
L
L
D
Rhesus Macaque
Macaca mulatta
XP_001089122
951
105836
S500
E
Q
L
E
A
A
S
S
Q
K
L
G
L
L
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8K3F6
873
96778
S422
E
Q
L
E
A
A
A
S
Q
K
L
G
L
L
D
Rat
Rattus norvegicus
O88944
873
96879
S422
E
Q
L
E
A
A
A
S
Q
K
L
G
L
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508650
831
93729
S371
E
Q
L
E
A
A
A
S
Q
K
L
G
L
L
D
Chicken
Gallus gallus
XP_001233489
841
93324
E382
I
P
P
L
N
Q
L
E
L
L
R
N
L
K
S
Frog
Xenopus laevis
P70057
377
42627
Zebra Danio
Brachydanio rerio
XP_697081
974
106699
S401
D
Q
G
E
S
A
T
S
Q
K
L
S
F
K
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
90.1
N.A.
N.A.
95.4
95.1
N.A.
76.9
49.6
22.3
37.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
90.6
N.A.
N.A.
97.1
97
N.A.
83.2
62.5
30.9
53.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
93.3
6.6
0
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
6.6
0
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
67
78
34
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
78
% D
% Glu:
67
0
0
78
0
0
0
12
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% F
% Gly:
0
0
12
0
0
0
0
0
0
0
0
67
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
78
0
0
0
23
0
% K
% Leu:
0
0
67
12
0
0
12
0
12
12
78
0
78
67
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
12
0
0
0
0
0
0
12
0
0
0
% N
% Pro:
0
12
12
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
78
0
0
0
12
0
0
78
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% R
% Ser:
0
0
0
0
12
0
34
78
0
0
0
12
0
0
12
% S
% Thr:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _